XEOMIN® (incobotulinumtoxinA) is a uniquely purified botulinum toxin that is free from complexing proteins and has the lowest foreign protein load among the available botulinum toxin preparations1, 2. By providing only the active neurotoxin for treatment, it might help reduce the risk of developing antibody-induced secondary treatment failure1, 2.

FDA approved. Clinically proven.

XEOMIN® is clinically proven with efficacy and safety studies done for the temporary improvement of the appearance of glabellar frown lines, lateral periorbital lines (crow’s feet) and horizontal forehead lines in adults.3

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How It Works

Dynamic facial wrinkles such as frown lines form when facial expressions are made as the muscle under the skin contracts. Over time, as skin ages, these repeated expressions cause these lines to deepen and become persistent. Botulinum toxins, such as Xeomin®, are prescription medications that block the release of chemicals from nerve endings that cause these muscle contractions so that these facial wrinkles are softened.

Xeomin® is manufactured through a unique precision purification process that isolates the therapeutic botulinum toxin component and removes the unnecessary bacterial components that don’t play an active role in treatment. A potential benefit of this is the reduced risk of developing neutralizing antibodies to the active neurotoxin, which may lead to less effective treatments or even complete treatment failure.1, 2
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Xeomin® is made through a unique precision manufacturing process that isolates the therapeutic component of the molecule and removes the necessary proteins that don’t play an active role in treatment. A potential benefit of this is the reduced risk of developing neutralizing antibodies to the active neurotoxin, which may lead to less effective treatments or even treatment failure.3, 4


What is Xeomin® used for?

Xeomin® is indicated for temporary improvement in the appearance of moderate to severe:

  • Upper facial lines
    • Glabellar frown lines
    • Lateral periorbital lines seen at maximum smile (crow’s feet lines)
    • Horizontal forehead lines

How do I know if Xeomin® is right for me?

Talk to your licensed and trained doctor to discuss the benefits and risks of treatment. Do not use Xeomin® if you are allergic to botulinum toxin or any of the other ingredients in Xeomin®. You should also not use Xeomin® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.

What should I tell my doctor before treatment?

Before receiving treatment with Xeomin®, you should tell your doctor about all of your medical conditions, including whether you have a disease that affects your muscles and nerves, have allergies to any botulinum toxin product, or have experienced any side effect from any other botulinum toxin in the past. In addition, tell your doctor about your medical history and all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you have received any other botulinum toxin product in the last four months or in the past. Be sure your doctor knows exactly which product(s) you received and when you received them.

What can I expect during treatment?

During treatment, which usually takes about 10-20 minutes, your doctor will inject Xeomin® into target muscles in your face using a fine needle. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.

When can I expect to see results?

You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

What are the most common side effects of Xeomin®?

Xeomin® may cause serious side effects, including allergic reactions. Symptoms of an allergic reaction to Xeomin® may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or seek medical help right away if you have wheezing, experience other asthma symptoms, or if you become dizzy or faint. In clinical trials of Xeomin® for the treatment of frown lines between the eyebrows, headache was the most common side effect. Xeomin® may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of taking Xeomin®. If this happens, do not drive a car, operate machinery, or do other dangerous activities. Tell your doctor if you have any side effect that bothers you or that does not subside. These are not all of the possible side effects of Xeomin®. For more information, refer to the approved product information or ask your doctor.

  1. Park JY et al. Neurotoxin impurities: A Review of threats to Efficacy. Plast Reconstr Surg Glob Open 2020;8(1):e2627.
  2. Kerscher M, et al. IncobotulinumtoxinA: A Highly Purified and Precisely Manufactured Botulinum Neurotoxin Type A. J Drugs Dermatol. 2019 Jan 1;18(1):52-57
  3. XEOMIN® Approved Product Information. September 2018.