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Belotero® Revive is an injectable resorbable implant intended to revitalize facial skin through rehydration, improvement of elasticity and firmness, and smoothening of superficial fine lines by reducing skin roughness.

Belotero® Revive is indicated for revitalization of early onset photodamaged facial skin, as characterized by dehydration, loss of elasticity and firmness, and presence of superficial fine lines.

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The Science Behind Belotero® Revive

Belotero® Revive combines hyaluronic acid (HA) and glycerol to enhance the skin’s health and give it a youthful and radiant look.1,2 Hyaluronic acid is naturally produced by the body
to provide hydration and support to the skin. It can hold 1,000 times its weight in water.

Glycerol is another strong hydration agent that serves as a humectant to lock in moisture in the skin. The synergy of these 2 moisture powerhouses – hyaluronic acid and glycerol delivers
strong, effective hydration, creating a lasting glow.2,3 The safety and efficacy of Belotero® Revive have been demonstrated in clinical studies that evaluated the product’s use in patients with early signs of sun-damaged skin.

The results from these studies showed that Belotero® Revive2,3:

  • Improved skin texture for up to 7 months ​
  • Increased skin firmness for up to 6 months ​
  • Provided deep hydration for up to 9 months  ​
  • Enhanced skin radiance* for up to 9 months

The Science Behind Belotero® Revive

Belotero® Revive combines hyaluronic acid (HA) and glycerol to enhance the skin’s health and give it a youthful and radiant look.1,2 Hyaluronic acid is naturally produced by the body
to provide hydration and support to the skin. It can hold 1,000 times its weight in water.

Glycerol is another strong hydration agent that serves as a humectant to lock in moisture in the skin. The synergy of these 2 moisture powerhouses – hyaluronic acid and glycerol delivers
strong, effective hydration, creating a lasting glow.2,3 The safety and efficacy of Belotero® Revive have been demonstrated in clinical studies that evaluated the product’s use in patients with early signs of sun-damaged skin.

The results from these studies showed that Belotero® Revive2,3:

  • Improved skin texture for up to 7 months ​
  • Increased skin firmness for up to 6 months ​
  • Provided deep hydration for up to 9 months  ​
  • Enhanced skin radiance* for up to 9 months

STANDARD CROSS-LINKING

Phase 1

Hyaluronic acid in its original form (single chains, random coil structure).

Phase 2

Linearization of the individual
hyaluronic acid chains. The
random coil structure untangles.

Phase 3

First hyaluronic cross-linking
process with BDDE (butanediol
diglycidyl ether). A cellular,
monophasic gel emerges.

PATENTED DYNAMIC CROSS-LINKING TECHNOLOGY (DCLT)

Phase 4

Expansion of the gel that was created in the cross-linking process.

Phase 5

A second application of hyaluronic
acid links the residual BDDE to the
fibers. The gel results in a Cohesive
Polydensified Matrix or CPM.

MULTIPLE DENSITY ZONES - HOW PRODUCT BEHAVES IN SKIN AFTER INJECTION4

Watch how it works

* Improvement in skin radiance defined by decrease in haemoglobin value and increase in melanin value as measured by a mexameter.2

References:
(1) BELOTERO Revive Instruction for use 2022 (2) Hertz-Kleptow D, et al. Clin Cosmet Investig Dermatol. 2019;12:563–572. (3) Kerscher M, et al. Plast Reconstr Surg Glob Open. 2021 Dec 3;9(12):e3973. (4) Tran C, et al. Dermatology. 2014;228(1):47-54

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