Long-Lasting Immediate Lift

Replenish volume. Restore collagen. Refresh you.

RADIESSE® and RADIESSE® (+) are Calcium Hydroxylapatite based dermal fillers that provide a triple effect of vertical lifting1,2, defining contours3-5 and neocollagenesis5-9.
They are used for the correction of moderate to severe facial winkles and folds, as well as for rejuvenation of the hands.
RADIESSE® is the first FDA-approved dermal filler for both the face and hands10,11.

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How It Works

Collagen is the main structural protein providing strength and support in the skin. As we age, the production of collagen slows down, causing skin to lose its firmness and elasticity.
RADIESSE stimulates the body’s natural process of generating new collagen.
Calcium hydroxylapatite (CaHA) forms the main active ingredient of RADIESSE®10. Metabolized naturally and completely biodegradable7,12, the CaHA microspheres are suspended in a carrier ideal for injection, with RADIESSE® (+) having added lidocaine for improved patient comfort13,14.
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Watch how it works

Calcium hydroxylapatite (CaHA) forms the unique cornerstone of RADIESSE®.3 Metabolized naturally and completely biodegradable7,8, the CaHA microspheres are suspended in a gel ideal for injection, with RADIESSE® (+) having added lidocaine for patient comfort.9,10


What is Radiesse® used for?

- Nasolabial folds and HIV lipoatrophy
RADIESSE injectable implant is indicated for subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and it is also intended for restoration and/or correction of the signs of facial fat loss (lipoatrophy) in people with human immunodeficiency virus.

- Hands
RADIESSE® injectable implant is indicated for hand augmentation to correct volume loss in the dorsum of the hands.

RADIESSE® (+) Lidocaine injectable implant is indicated for plastic / reconstructive procedures, including deep dermal and subdermal soft tissue augmentation of the facial area and is also intended for restoration and correction of fat or volume loss (lipoatrophy) in the facial area and for rejuvenation of the hands.

Has Radiesse® been tested and certified?

In 2003, Radiesse® achieved CE Certification, the European Union standard for product safety. In 2006, Radiesse® was also approved by the FDA, the American Regulatory Authority. Most recently, Radiesse® is the first facial filler to receive US-FDA approval for Hand augmentation. Radiesse® has more than 250 publications and is proven to be safe and effective.

How soon will I see the results after Radiesse®?

Generally, the volumization and wrinkle-filling effect will be visible immediately after injection. Radiesse® and Radiesse® Lidocaine works to lift and define key areas around the lower face for an overall smoother appearance. By stimulating your body’s own natural collagen production, the effects of skin quality improvement by Radiesse® will continue over time.

How long do the effects of Radiesse® last?

The duration of the results depends on age, skin type, lifestyle and metabolism, and of course, the area treated. Radiesse® results are usually durable and can last up to 12 months in many patients.

What does the procedure involve?

Radiesse® is gently injected into the skin, usually in small amounts, with a fine needle or cannula. Radiesse® is usually injected under the skin in the middle and lower face, as well as the dorsum of hands. One treatment session typically lasts around 30 minutes, but might take longer if multiple areas are being treated in the same session.

Are there any side effects?

Most adverse reactions are injection-site related and often transient. These include slight redness, swelling, itching, bruising, and pain at injection sites. They are generally mild to moderate in severity and disappear on their own shortly after injection (typically within one or two days).

Less common reactions such as inflammation, infection, fistulisation, hardening, and slight discolouration of the treated areas may also occur. If you suffer from poor wound healing, delayed healing may occur. Rare but serious adverse events associated with the intravascular injection of soft tissue fillers in the face have been reported and include temporary or permanent vision impairment, blindness, cerebral ischemia or cerebral hemorrhage, leading to stroke, skin necrosis, and damage to underlying facial structures.

Prior to treatment, your Healthcare Practitioner will inform you about the possible risks and side effects.

Can Radiesse® be felt under the skin?

The filler may be felt for a short time after the treatment until it completely integrates with the skin.

  1. Van Loghem JV, et al. Van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49J Clin Aesthet Dermatol. 2015;8(1):38-49.
  2. Sundaram H, et al. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg. 2010;36 Suppl 3:1859-65.
  3. Dallara JM, et al. Calcium hydroxylapatite for jawline rejuvenation: consensus recommendations. J Cosmet Dermatol. 2014;13(1):3-14.
  4. Eviatar J, et al. Radiesse: Advanced Techniques and Applications for a Unique and Versatile Implant. Plast Reconstr Surg. 2015 Nov;136(5 Suppl):164-170.
  5. Yutskovskaya Y, et al. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014;13(9):47-52.
  6. Yutskovskaya YA, Kogan EA. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Décolletage:A Pilot Study. J Drugs Dermatol. 2017;16(1):68-74.
  7. Marmur ES, et al. Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler. J Cosmet Laser Ther. 2004;6(4):223-6.
  8. Berlin AL, et al. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34(suppl 1):S64-S67.
  9. Zerbinati N, et al. Calcium hydroxylapatite treatment of human skin: evidence of collagen turnover through picrosirius red staining and circularly polarized microscopy. Clin Cosmet Investig Dermatol. 2018;11:29-35.
  10. RADIESSE® [Instructions for Use]. Franksville, WI: Merz North America, Inc.; 2016.
  11. RADIESSE® [Instructions for Use for the dorsum of the hand]. Franksville, WI: Merz North America, Inc.; 2016.
  12. Pavicic T. Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin Cosmet Investig Dermatol. 2015;8:19-25.
  13. Schachter D, et al. Open-Label, Post-Marketing Study to Evaluate the Performance and Safety of Calcium Hydroxylapatite With Integral Lidocaine to Correct Facial Volume Loss. J Drugs Dermatol. 2016;15(8):1005-10.
  14. Muti GF. Open-Label, Post-Marketing Study to Evaluate the Performance and Safety of Calcium Hydroxylapatite With Integral Lidocaine to Correct Facial Volume Loss. J Drugs Dermatol. 2019;18(1):86-91.