Long-Lasting Immediate Lift

Replenish volume. Restore collagen. Refresh you.

RADIESSE® and RADIESSE® (+) are Calcium Hydroxylapatite based dermal fillers that provide a triple effect of vertical lifting1,2, defining contours3-5 and neocollagenesis5-9.
They are used for the correction of moderate to severe facial winkles and folds, as well as for rejuvenation of the hands.
RADIESSE® is the first FDA-approved dermal filler for both the face and hands10,11.

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How It Works

Collagen is the main structural protein providing strength and support in the skin. As we age, the production of collagen slows down, causing skin to lose its firmness and elasticity.
RADIESSE stimulates the body’s natural process of generating new collagen.
Calcium hydroxylapatite (CaHA) forms the main active ingredient of RADIESSE®10. Metabolized naturally and completely biodegradable7,12, the CaHA microspheres are suspended in a carrier ideal for injection, with RADIESSE® (+) having added lidocaine for improved patient comfort13,14.
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Watch how it works

Calcium hydroxylapatite (CaHA) forms the unique cornerstone of RADIESSE®.3 Metabolized naturally and completely biodegradable7,8, the CaHA microspheres are suspended in a gel ideal for injection, with RADIESSE® (+) having added lidocaine for patient comfort.9,10
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FAQs

What does the procedure involve?

Radiesse® is gently injected into the skin, usually in small amounts, with a very fine needle or cannula. The duration will depend on the number of treatment areas.

What is the difference between Radiesse®and Radiesse®+?

How is Radiesse® absorbed by the body?

As a fully biodegradable dermal treatment, Radiesse® will gradually be broken down to calcium and phosphate ions and be absorbed by your body naturally over time. 7,12,16,17

Has Radiesse® been tested and cerified??

Yes. Radiesse® has received both U.S. FDA approval and EU CE mark.

What should I pay attention to after treatment?

Things to do

  • Keep treated area cooled to prevent or reduce swelling 10
  • Avoid applying pressure for 12 to 24 hours
  • Avoid extreme warmth or UV light
  • Avoid make-up 12 hours after treatment

Things to note

  • Avoid treatment if you have a skin infection 10
  • If you have a history of herpes, you may experience a herpes breakout after treatment10
  • Radiesse® microspheres may be visible on X-rays and CT scans

How long do the effects of Radiesse®last?

Depending on the individual’s treatment area, age, skin type, lifestyle and metabolism, Radiesse® effects may last up to 2 years.15

How quickly can I return to work after a Radiesse®treatment?

Due to the safety and tolerability of Radiesse®, you will experience minimal to no downtime after treatment, allowing you to return to work quickly.15

Can Radiesse®be used with other products?

Please consult your aesthetic physician for the possibility of combination treatments within the Merz Aesthetics portfolio, such as Incobotulinum Toxin A, MFU-V, and Cohesive Polydensified Matrix® hyaluronic acid filler.

How can I learn more about Radiesse®?

Ask your aesthetic physician if Radiesse® is right for you.

  1. Van Loghem JV, et al. Van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49J Clin Aesthet Dermatol. 2015;8(1):38-49.
  2. Sundaram H, et al. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg. 2010;36 Suppl 3:1859-65.
  3. Dallara JM, et al. Calcium hydroxylapatite for jawline rejuvenation: consensus recommendations. J Cosmet Dermatol. 2014;13(1):3-14.
  4. Eviatar J, et al. Radiesse: Advanced Techniques and Applications for a Unique and Versatile Implant. Plast Reconstr Surg. 2015 Nov;136(5 Suppl):164-170.
  5. Yutskovskaya Y, et al. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014;13(9):47-52.
  6. Yutskovskaya YA, Kogan EA. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Décolletage:A Pilot Study. J Drugs Dermatol. 2017;16(1):68-74.
  7. Marmur ES, et al. Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler. J Cosmet Laser Ther. 2004;6(4):223-6.
  8. Berlin AL, et al. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34(suppl 1):S64-S67.
  9. Zerbinati N, et al. Calcium hydroxylapatite treatment of human skin: evidence of collagen turnover through picrosirius red staining and circularly polarized microscopy. Clin Cosmet Investig Dermatol. 2018;11:29-35.
  10. RADIESSE® [Instructions for Use]. Franksville, WI: Merz North America, Inc.; 2016.
  11. RADIESSE® [Instructions for Use for the dorsum of the hand]. Franksville, WI: Merz North America, Inc.; 2016.
  12. Pavicic T. Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin Cosmet Investig Dermatol. 2015;8:19-25.
  13. Schachter D, et al. Open-Label, Post-Marketing Study to Evaluate the Performance and Safety of Calcium Hydroxylapatite With Integral Lidocaine to Correct Facial Volume Loss. J Drugs Dermatol. 2016;15(8):1005-10.
  14. Muti GF. Open-Label, Post-Marketing Study to Evaluate the Performance and Safety of Calcium Hydroxylapatite With Integral Lidocaine to Correct Facial Volume Loss. J Drugs Dermatol. 2019;18(1):86-91.
  15. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.
  16. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
  17. Chang JW, et al. J Craniofac Surg. 2020;31(1):e18–21.

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