Long-Lasting Immediate Lift

Replenish volume. Restore collagen. Refresh you.

About RADIESSE® and RADIESSE® (+)

RADIESSE® and RADIESSE® (+) are Calcium Hydroxylapatite (CaHA)-based dermal fillers designed to deliver both immediate volume correction1-5 and long-term regenerative biostimulation6,8,9,15. Through collagen, elastin, and proteoglycan production, RADIESSE® helps restore a more youthful appearance with natural-looking results.11,13,14,18-21

RADIESSE® is indicated for treatment of moderate to severe nasolabial folds, moderate to severe cheek augmentation to restore volume, Hand augmentation to correct volume loss in the dorsum of the hands and restoration and/or correction of facial lipoatrophy in individuals with HIV.5

RADIESSE® Injectable Implant diluted 1:2 with 0.9% sterile saline is indicated for the treatment of moderate to severe décolleté wrinkles via production of collagen, elastin and proteoglycans.

RADIESSE® (+) is indicated for plastic and reconstructive procedures, including deep dermal and subdermal soft tissue augmentation of the facial area. It is also intended for the restoration and correction of facial fat or volume loss (lipoatrophy) and hand rejuvenation.5

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How It Works

Beneath the surface lies your skin’s own ecosystem, known as the extracellular matrix (ECM). Here, the dermal fibroblasts primarily produce ECM components and contribute to their structural organization. Key ECM components include:

  • Collagen type three and type one, which provide structure and support2,11,20,22-24
  • Elastin, providing elasticity and stretch25-26
  • Proteoglycans, providing tissue hydration9,25,26
  • Angiogenesis for nourishment and long-term support for healthy, new tissues2
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As we age, a decrease in fibroblast activity and mechanical interaction reduce the production of ECM components, affecting ECM structure and causing the skin to lose its firmness and elasticity.

RADIESSE®’s one-of-a-kind calcium hydroxylapatite microspheres reawakens the dermal fibroblasts within your skin’s ECM through a non-inflammatory mechanism of action. This causes the regeneration of key components of the ECM that provides the foundation for healthy and youthful looking skin as well as deliver immediate lift and contour.6,8,9,15

Watch how it works

Calcium hydroxylapatite (CaHA) forms the unique cornerstone of RADIESSE®.3 Metabolized naturally and completely biodegradable7,8, the CaHA microspheres are suspended in a gel ideal for injection, with RADIESSE® (+) having added lidocaine for patient comfort.9,10
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FAQs

What does the procedure involve?

Radiesse® is gently injected into the skin, usually in small amounts, with a very fine needle or cannula. The duration will depend on the number of treatment areas.

How can Radiesse® and Radiesse®+ be used?

How is Radiesse® absorbed by the body?

As a fully biodegradable dermal treatment, Radiesse® will gradually be broken down to calcium and phosphate ions and be absorbed by your body naturally over time. 7,12,16,17

Has Radiesse® been reviewed and certified?

Yes. Radiesse® has received both U.S. FDA approval and EU CE mark.

What should I pay attention to after treatment?

Things to do

  • Keep treated area cooled to prevent or reduce swelling10
  • Avoid applying pressure for 12 to 24 hours
  • Avoid extreme warmth or UV light
  • Avoid make-up 12 hours after treatment

Things to note

  • Avoid treatment if you have a skin infection10
  • If you have a history of herpes, you may experience a herpes breakout after treatment10
  • Radiesse® microspheres may be visible on X-rays and CT scans

How long do the effects of Radiesse® last?

Depending on the individual’s treatment area, age, skin type, lifestyle and metabolism, Radiesse® effects may last up to 2 years.15, 27-31

How quickly can I return to work after a Radiesse® treatment?

Due to the safety and tolerability of Radiesse®, you will experience minimal to no downtime after treatment, allowing you to return to work quickly.15

How can I learn more about Radiesse®?

Ask your aesthetic physician if Radiesse® is right for you.

  1. Meland M, et al. J Drugs Dermatol. 2016;15(9):1107-1110.
  2. Sundaram H, et al. Dermatol Surg. 2010;36(suppl 3):1859-1865.
  3. Sundaram H, et al. Plast Reconstr Surg. 2013;132(4 suppl 2):5S-21S.
  4. de la Guardia C, et al. Facial Plast Surg. 2022;38(2):116-123.
  5. Radiesse Instructions for use. Merz Nor¤h America, Inc.
  6. Muti GF, et al. J Drugs Dermatol. 2015:14(9):948-54.
  7. Marmur ES, et al. Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler. J Cosmet Laser Ther. 2004;6(4):223-6.
  8. van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
  9. Durkin A, et al. J Cosmet Dermatol. 2021 Feb;20(2):442-450.
  10. RADIESSE® [Instructions for Use]. Franksville, WI: Merz North America, Inc.; 2016.
  11. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-52.
  12. Pavicic T. Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin Cosmet Investig Dermatol. 2015;8:19-25.
  13. Yutskovskaya YA, Kogan EA. J Drugs Dermatol. 2017;16(1):68-74.
  14. Goldie K. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:1-7
  15. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.
  16. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
  17. Chang JW, et al. J Craniofac Surg. 2020;31(1):e18–21.
  18. Corduf N. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:8-14
  19. Amiri M, et al. Front Med (Lausanne). 2023 Jun 2;10:1195934.
  20. González N, Goldberg DJ. Dermatol Surg. 2019 Apr;45(4):547-551.
  21. Kim J. Clin Cosmet Investig Dermatol. 2019 Oct 15;12:771-784.
  22. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.
  23. Zerbinati N. Clin Cosmet Investig Dermatol. 2018;11:29-35.
  24. van Rozelaar L, et. al. Aesthet Surg J. 2014;34(1):118-132.
  25. Muti GF. J Drugs Dermatol. 2019;18(1):86-91.
  26. Schachter D, et al. J Drugs Dermatol. 2016;15(8):1005-10.
  27. Pavicic T. Clin Cosmet Investig Dermatol. 2015;8:19–25.
  28. Powell MF. Analy¤ical Profiles Drug Subst. 1986;15:761-779.
  29. Radiesse Patient Information Guide (PIG)
  30. Radiesse (+) Patient Information Guide (PIG)
  31. Radiesse Hands Patient Information Guide (PIG)

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